Rams' Cooper Kupp leaves with ankle injury in blowout loss to Cardinals

Los Angeles Rams wide receiver Cooper Kupp left Sunday's 41-10 defeat to the Arizona Cardinals early with an ankle injury.

The Rams announced in the third quarter that he was doubtful to return. He was seen in a walking boot on his left leg as he left the locker room after the loss at State Farm Stadium outside of Phoenix. It's unclear how severe the injury is, and Rams head coach Sean McVay didn't have much of an update after the game.

The injury is a potentially significant blow to a Rams team that's already without Pro Bowl wide receiver Puka Nacua, who's on injured reserve and is reportedly expected to miss up to seven weeks with a PCL sprain suffered in Week 1. Demarcus Robinson and Tyler Johnson are next up on the the Rams' depth chart.

Kupp appeared to sustain the injury in the first half on Sunday when his left ankle rolled on a tackle. He received treatment on the sideline and eventually walked off the field with the assistance of an athletic trainer. The Rams didn't provide further details about his injury during the game.

A former All-Pro and the 2021 NFL Offensive Player of the Year, Kupp has been limited by injuries in each of the previous two seasons. He played in 21 of a possible 34 regular-season games in 2022 and 2023.

He finished Sunday with four catches for 37 yards on six targets.

Kupp was healthy entering the 2024 season and thrived in Nacua's absence last week, tallying 14 catches for 110 yards and a touchdown in a flashback to his 2021 form.

The Rams, after their 26-20 loss to the Detroit Lions last week, are now 0-2 on the season. They'll host the San Francisco 49ers next week.